Edward and Alphonse Elric are two alchemist brothers searching for the legendary catalyst called the Philosopher's Stone, a powerful object which would allow them to recover their bodies (which were lost in an attempt to bring their mother back to life through alchemy). Born in the village of Resembool from the country of Amestris the two brothers lived there with their mother Trisha Elric. Their father, Van Hohenheim, left home for unknown reasons and years later, their mother, Trisha Elric died of a terminal illness, leaving the Elric brothers alone. After their mother's death, Edward became determined to bring her back through the use of alchemy, an advanced science in which objects can be created from raw materials. They researched Human Transmutation, a forbidden art in which one attempts to create or modify a human being. However, this attempt failed, ultimately resulting in the loss of Edward's left leg and Alphonse's entire body. In a desperate effort to save his brother, Edward sacrificed his right arm to affix Alphonse's soul to a suit of armor. Some days later, an alchemist named Roy Mustang visited the Elric brothers, and proposed that Edward become a member of the State Military of the country in exchange for more research materials to find a way to recover their bodies. After that, Edward's left leg and right arm were replaced with automail, a type of advanced prosthetic limb, created for him by his close family friends Winry Rockbell and her grandmother Pinako.
Edward then became a State Alchemist an alchemist employed by the State Military of Amestris, which infamously annihilated most of the Ishbalan race in the past decade. Becoming a State Alchemist enables Edward to use the extensive resources available to State Alchemists. The brothers set off in search of the Philosopher's Stone as a means to restore their bodies. Throughout their journey, they meet many antagonists, including those who are willing to do anything to obtain the Philosopher's Stone
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The series begins with the execution of Gold Roger, a man known as the King of the Pirates. Just before his death, Roger announces that his treasure, the One Piece , will be up for the taking, causing the Great Pirate Era to begin. As a result, countless pirates set out to the Grand Line to look for the treasure.
Twenty years have passed since Roger's execution, and Monkey D. Luffy a young pirate inspired by the pirate known as "Red-Haired" Shanks, has since set off on a journey from the East Blue to succeed Roger and find the treasure. He organizes and leads a nine-member crew named the Straw Hat Pirates. Each crew member Luffy encounters eventually become his close friends, including the swordsman Roronoa Zoro, the navigator and thief Nami, the sniper Usopp, the womanizing chef and martial artist Sanji, the doctor and anthropomorphized reindeer Tony Tony Chopper, the archaeologist Nico Robin, the cybernetic shipwright Franky, and the musician skeleton Brook.
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